Innovative Work of IPB Lecturers, Created Medication for Burn Wounds and Anti-diarrhea Eggs from Bacteria
The faculty member of the Department of Biology of the Faculty of Mathematics and Natural Sciences of Bogor Agricultural University (FMIPA IPB), Dr. dr Sri Budiarti, recently discovered a bacteriophage of cattle manure which can later be developed as spray bacteriophage for the treatment of burn wounds. A bacteriophage also known informally as a phage, is a virus that infects and replicates within a bacterium. The term is derived from "bacteria" and the Greek: (phagein), "to devour".
"She expected that in the future, this bacteriophage can be utilized as a product to treat burns," she said.
In the year 2002-2015, Dr. dr. Sri Budiarti was assigned to take post as the Head of polyclinic of IPB. During which she explained about the burning patients. Unlike other types of injury, burn wounds induce metabolic and inflammatory alterations that predispose the patient to various complications. Infection is the most common cause of morbidity and mortality in this population, with almost 61% of deaths being caused by infection. The skin provides primary protection against infection by acting as a physical barrier. When this barrier is damaged, pathogens can directly infiltrate the body, resulting in infection. Therefore, antimicrobial therapy to treat an underlying infection, to reduce morbidity, and to prevent mortality is really needed.
Dr. Sri herself who focuses who involves in microbiology, especially medical microbiology which has important roles as it is beneficial for humans. One of her discoveries has been the adhesion factor of Escherichia coli bacteria that can utilized as antibodies. One of them is that it can be used as an antibody.
Another discovery is the adhesion factor of the bacteria Escherichia coli. " Adhesion is the first step in colonization or infection and is facilitated by fimbrial or afimbrial adhesins which bind to host cell receptors. Tissue and host specificity is then determined on the basis of bacterial expression. Bacterial intestinal colonization of a host is influenced by the ability of the bacterium to inhabit an intestinal niche which is not occupied by competing bacteria. So the bacteria that enter the human cell must be attached to the cell surface so that there is a protein that can be expressed called adhesin factor, then it can utilized as antibodies., "she said. Furthermore, together with Prof Fachriyan Pasaribu of the Faculty of Veterinary Medicine of Bogor Agriultural University (FKH IPB), the findings were developed into antidiarrhea eggs.
"Making antidiarrhea eggs is by adding bacteria into the chicken feed. The human body constantly faces attack from foreign invaders that can cause infection and disease, they have to be prevented. Eggs that contain antibodies will increase the body's defenses so that bacterial diseases may decrease, "she said. (Wied)
