Wow! Extract Sea Worm (Shiponosoma australe) Capsules for Antidiabetes
What is diabetes mellitus? To fully understand what diabetes mellitus is we need to understand the normal human anatomy and physiology. Diabetes is a complex group of diseases with a variety of causes. People with diabetes have high blood glucose, also called high blood sugar or hyperglycemia. Diabetes develops when the body doesn’t make enough insulin or is not able to use insulin effectively, or both. Insulin is made in the pancreas, an organ located behind the stomach. The pancreas contains clusters of cells called islets. Beta cells within the islets make insulin and release it into the blood. In other words, there would not be any symptom till the time there has already been great damage to your body organs. And when symptoms appear, diabetic complications are usually in an untreatable stage. Diabetes is often called the silent killer because of its easy-to-miss symptoms. And hence, silent killer. Treatment of diabetes is usually done by oral drug delivery and insulin hormone injection.
Changing lifestyle could be a big step toward diabetes prevention, where we are advised eating more healthfully, becoming more physically active and losing a few extra pounds. One area of confusion for diabetics and their diets is carbohydrates. So, should you eat carbohydrates or avoid them? People Back to Nature, people around the world spend every working day ‘connected to nature’ and appreciate full well their dependence on natural water supplies and how nature provides their livelihoods in the form of fertile soil, herbs for herbal medicines. This is the reason why the student of Bogor Agricultural University (IPB), namely Anisa Utami R. Zahra to carry out the research program on " Karakteristik Kapsul Antidiabetes dari Ekstrak Cacing Laut (Shiponosoma australe) = Characteristics of Extract Sea Worm (Shiponosoma australe) Capsules for Antidiabetes".
Anisa is a member of a team of Sipuncula-related sea worm research project headed by Prof. Dr. Ir. Sri Purwatiningsih, MSi from the Department of Technology of Fishery Results of the Faculty of Fishery and Marine Sciences (FPIK IPB). Anisa explained that this research was conducted to determine the quality of raw materials, chemical components in marine worm extracts, and make the preparation of drugs in accordance with quality requirements. For this research project a capsule preparation is made.
Previously, the S. australe marine ethanol extract was undertook preclinical test with Antihyperglycemic activity, but the development of the extract into a standardized drug has not been studied further.
"Further research related to the development and characterization of standardized herbal medicines from S. australe marine worm extracts needs to be carried out for its sustainability," she said.
Anisa revealed that worm S. australe is not contaminated by heavy metals and microbial pathogens, therefore it is safe to process further for the raw material drug. Polar solvents i.e. ethanol was used for extraction, was carried out to provide the highest rendement and inhibitory activity against the α-glucosidase enzyme.
The Pancreatic α-glucosidase and alpha amylase inhibitors offer an effective strategy to lower the level of post prandial hyperglycemia via control of starch breakdown. The bioactive compounds of extracts of S. australe worms are flavonoids, alkaloids, saponins, and steroids.
The research found out that the capsule caps meet the requirements of the drug preparation stipulated by BPOM which should have water content of 2.20 percent, uniformly sized with crushed time for 16 minutes 15 seconds, and meet the maximum limit of contamination contained in the requirements.
'Hopefully the efficacy of marine worm extract will create added value that can improve the value of S. australe sea worms as a raw material of aquatic products. Finally, it expected that the present research will add other source of new information and the traditional source of new pharmaceuticals." she added. (Wied)
